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CCS-1477(CBP-IN-1)

Cat. No. M20798
CCS-1477(CBP-IN-1) Structure
Synonym:

CBP-IN-1, CBP/p300-IN-4

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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

CCS1477(CBP-IN-1, CBP/p300-IN-4)is a potent and selective inhibitor of p300/CBP bromodomain. CCS1477 works by inhibiting the expression and function of the androgen receptor (AR), as well as inhibiting c-Myc.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 534.6
Formula C30H32F2N4O3
CAS Number 2222941-37-7
Purity >99%
Solubility DMSO 100 mg/mL
Storage at -20°C
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Inobrodib (CCS1477) is an orally active, potent and selective p300/CBP inhibitor. inobrodib binds to p300 and CBP with Kd values of 1.3 and 1.7 nM and has a 170/130 fold selectivity compared to BRD4 with a Kd of 222 nM. ccs1477 acts by inhibiting CCS1477 acts by inhibiting the expression and function of androgen receptor (AR) and by inhibiting c-Myc.

  Catalog
Abmole Inhibitor Catalog




Keywords: CCS-1477(CBP-IN-1), CBP-IN-1, CBP/p300-IN-4 supplier, Epigenetic Reader Domain, inhibitors

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