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Aminophylline

Cat. No. M3588
Aminophylline Structure
Size Price Availability Quantity
100mg USD 54  USD60 In stock
500mg USD 90  USD100 In stock
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Quality Control
Biological Activity

Aminophylline (Phyllocontin, Truphylline) is a competitive nonselective phosphodiesterase inhibitor with an IC50 of 0.12 mM and also a nonselective adenosine receptor antagonist. It is a bronchodilator. It is a compound of the bronchodilator theophylline with ethylenediamine in 2:1 ratio.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 420.43
Formula C16H24N10O4
CAS Number 317-34-0
Purity 100.0%
Solubility DMSO 50 mg/mL
Water 80 mg/mL
Storage at -20°C
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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Aminophylline supplier, PDE, inhibitors

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