Acetaldehyde is a TRP anchor protein 1 (TRPA1) agonist that is converted to non-toxic acetic acid by acetaldehyde dehydrogenase (ALDH).
| Molecular Weight | 44.05 |
| Formula | C2H4O |
| CAS Number | 75-07-0 |
| Form | Liquid |
| Storage | 2-8°C |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[2] Richard A Deitrich et al. Novartis Found Symp. Removal of acetaldehyde from the body
[3] Richard A Deitrich. J Stud Alcohol. Acetaldehyde: déjà vu du jour
[4] No authors listed. IARC Monogr Eval Carcinog Risks Hum. Acetaldehyde
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