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8-Hydroxyquinoline

Cat. No. M5377
8-Hydroxyquinoline Structure
Synonym:

8-Oxychinolin, 8-Quinolinol, Oxine

Size Price Availability Quantity
500mg USD 30  USD30 In stock
1g USD 40  USD40 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

8-hydroxyquinoline is a mono-proton bicyclic chelator that is used as a preservative, disinfectant, and insecticide and as a transcription inhibitor. Is a kind of antiseptic with mild inhibition of fungi, bacteria, insect repellent, killing amoeba characteristics, is a strong copper ion carrier, can be used for copper death research.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 145.16
Formula C9H7NO
CAS Number 148-24-3
Purity >99%
Solubility 10mM in DMSO
Storage at -20°C
References

[1] Gomes LM, et al. J Inorg Biochem. 8-Hydroxyquinoline Schiff-base compounds as antioxidants and modulators of copper-mediated Aβ peptide aggregation.

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Keywords: 8-Hydroxyquinoline, 8-Oxychinolin, 8-Quinolinol, Oxine supplier, Cuproptosis, inhibitors

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