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8-hydroxyquinoline is a mono-proton bicyclic chelator that is used as a preservative, disinfectant, and insecticide and as a transcription inhibitor. Is a kind of antiseptic with mild inhibition of fungi, bacteria, insect repellent, killing amoeba characteristics, is a strong copper ion carrier, can be used for copper death research.
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
| Molecular Weight | 145.16 |
| Formula | C9H7NO |
| CAS Number | 148-24-3 |
| Purity | >99% |
| Solubility | 10mM in DMSO |
| Storage | at -20°C |
| Related Cuproptosis Products |
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| Disulfiram
Disulfiram is used in the study of chronic alcoholism with acute sensitivity to alcohol and is a potent copper ion-carrier that can be used in the study of copper death. |
| Zinc Pyrithione
Zinc Pyrithione is an anti-fungal and anti-bacterial drug that disrupts membrane transport by blocking proton pumps and is a potent copper ion carrier that can be used in copper death studies. |
| NSC 319726
NSC 319726 is a p53(R175) mutant activator that inhibits the growth of cells expressing mutant p53. It acts on p53(R175) mutant with IC50 of 8 nM and has no inhibition on p53 wild-type cells. It is a powerful copper ion-carrier and can be used for the study of copper death. |
| Elesclomol
Elesclomol (STA-4783) is a novel oxidative stress inducer that acts on tumor cells and promotes their apoptosis, and is a strong copper ion carrier that can be used for copper death research. |
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