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6-Aminopenicillanic acid

Cat. No. M19941
6-Aminopenicillanic acid Structure
Size Price Availability Quantity
500mg USD 50  USD50 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

6-Aminopenicillanic acid (6-APA) is the central component of penicillin β-lactam antibiotics which are generated by Penicillium. It is used as precursor for antibiotic compounds ampicillin and amoxicillin.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 216.26
Formula C8H12N2O3S
CAS Number 551-16-6
Purity >99%
Solubility DMSO 1 mg/mL
Storage at -20°C
References

[1] Nona Soleimanpour Moghadam, et al. Drug Dev Ind Pharm. Improving the 6-Aminopenicillanic acid release process using vermiculite-alginate biocomposite bead on drug delivery system

[2] Farzaneh Ghazizadeh Ahsaie, et al. Sci Rep. Separation of phenyl acetic acid and 6-aminopenicillanic acid applying aqueous two-phase systems based on copolymers and salts

[3] Amol M Sawant, et al. ACS Omega. Process Development for 6-Aminopenicillanic Acid Production Using Lentikats-Encapsulated Escherichia coli Cells Expressing Penicillin V Acylase

[4] G N Rolinson, et al. Int J Antimicrob Agents. The 50th anniversary of the discovery of 6-aminopenicillanic acid (6-APA)

[5] G N ROLINSON. Sci Rep Ist Super Sanita. 6-Aminopenicillanic acid

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