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3,4,5-Trimethoxyphenylacetic acid

Cat. No. M4943
3,4,5-Trimethoxyphenylacetic acid Structure
Size Price Availability Quantity
500mg USD 30  USD30 In stock
1g USD 40  USD40 In stock
5g USD 55  USD55 In stock
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Quality Control & Documentation
Biological Activity

When grown at the expense of 3,4,5-trimethoxyphenylacetic acid, a species of Arthrobacter readily oxidized 3,4-dihydroxy-5-methoxyphenylacetic acid, but other structurally related aromatic acids were oxidized only slowly. Cell extracts contained a dioxygenase for 3,4-dihydroxy-5-methoxyphenylacetate, and the corresponding trihydroxy acid, which was not attacked by the enzyme, inhibited oxidation of this ring-fission substrate.

Chemical Information
Molecular Weight 226.23
Formula C11H14O5
CAS Number 951-82-6
Form Solid
Solubility (25°C) DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Donnelly MI,et.al. J Bacteriol Bacterial degradation of 3,4,5-trimethoxyphenylacetic and 3-ketoglutaric acids.

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