About 5 results found for searched term "Necrostatin-1" (0.127 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M2315 | Necrostatin-1 | RIPK |
| Nec-1 | ||
| Necrostatin-1 (NEC-1) is a potent inhibitor of necroptosis, with an EC50 of 490 nM in Jurkat cells. Necrostin-1 is the first identified RIPK1 inhibitor, EC50=182 nM, that reduces inflammation and inhibits colitis associated tumorigenesis. Necrostatin-1 (Nec-1) is also an inhibitor of IDO. | ||
| M10602 | Necrostatin 2 racemate | RIPK |
| Nec-1s; Necrostatin 1S; 7-Cl-O-Nec-1 | ||
| Necrostatin-2 racemate (also known as 7-Cl-O-Nec-1 and Nec-1s) is a potent and specific receptor-interacting protein kinase 1 (RIPK1) inhibitor lacking the IDO-targeting effect, with >1000-fold more selective for RIPK1 than for any other kinase out of 485 human kinases. | ||
| M7942 | Necrostatin-5 | RIPK |
| Necrostatin-5 is an inhibitor of necroptosis (non-apoptotic cell death pathway) by indirect inhibition of RIP1 kinase. | ||
| M13556 | Necrostatin 2 | RIPK |
| Necrostatin 2 is a potent necroptosis inhibitor. EC50 for inhibition of necroptosis in FADD-deficient Jurkat T cells treated with TNF-α is 0.05 μM. Necrostatin 2 is also a RIPK1 inhibitor. | ||
| M21567 | Necrostatin-34 | RIPK |
| Necrostatin 34 (Nec-34) is an inhibitor of RIPK1 kinase that stabilizes RIPK1 in a deactivated state by occupying specific binding pockets in the kinase domain. | ||
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