About 1 result found for searched term "ARV-471" (0.128 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M21158 | Vepdegestrant (ARV-471) | PROTAC |
| ARV471; 2229711-08-2; PF-07850327 | ||
| Vepdegestrant (ARV-471) is an oral estrogen receptor PROTAC protein degrader for breast cancer.ARV-471 is a heterobifunctional molecule that promotes the interaction between estrogen receptor alpha and intracellular E3 ligase complexes.ARV-471 causes ubiquitination and subsequent degradation of the estrogen receptor via the proteasome.ARV-471 potently degrades ER-positive The ER in breast cancer cell lines is potently degraded by ARV-471 with a DC50 value of approximately 2 nM. | ||
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