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Cat.No. Name Target Information
M1637 ABT-263 Bcl-2 ABT-263 (Navitoclax) is a potent, orally bioavailable inhibitor of the antiapoptotic Bcl-2 family members Bcl-2, Bcl-x (L), and Bcl-w.
M1647 AMG-208 c-Met AMG-208 is a potent small molecular inhibitor c-Met with an IC50 of 9.3 nM.
M1648 AP24534 Src-bcr-Abl Ponatinib (AP24534) is a novel potent, orally available small molecule multitargeted kinase inhibitor of BCR-ABL, PDGFRα, c-Src, c-Kit, FGFR and VEGFR.
M1661 AZD6244 MEK AZD6244 (ARRY-142886, Selumetinib) is a potent MEK 1/2 inhibitor with GI50 values ranging from 14 to 50 nM.
M1664 AZD2281 PARP AZD 2281 (Olaparib, KU-0059436) is a potent PARP (poly ADP-ribose polymerase) inhibitorwith IC50 of 5 and 1 nM for PARP-1and PARP-2 respectively.
M1669 Regorafenib VEGFR/PDGFR Regorafenib (BAY 73-4506) is a novel oral multikinase inhibitor of c-KIT, VEGFR2, B-Raf with IC50s of 17, 40 and 69 nM respectively.
M1671 BEZ235 PI3K BEZ235 (NVP-BEZ235) is a potent dual PI3K and mTOR inhibitor of p110α, p110γ, p110δ and p110β with IC50 of 4 nM, 5 nM, 7 nM and 75 nM, respectively.
M1677 BIBW2992 EGFR/HER2 BIBW2992 (Afatinib) is a novel irreversible dual EGFR and HER2 tyrosine kinase inhibitor.
M1680 BKM120 PI3K BKM120 (NVP-BKM120) is a potent and highly specific oral pan-class I PI3K inhibitor.
M1686 Bortezomib Proteasome Bortezomib (Velcade) is a highly selective proteasome inhibitor with a ki value of 6nM.
M1692 CHIR-99021 GSK-3 CHIR-99021 (CT99021) is an aminopyrimidine derivative that inhibits GSK3α and GSK3β with IC50 values of 10 and 6.7 nM, respectively.
M1700 CYT387 JAK CYT387 is a small-molecule, ATP-competitive JAK1/JAK2 inhibitor with IC50 of 11 and 18 nM respectively.
M1701 Dasatinib Src-bcr-Abl Dasatinib (BMS-354825) is a small molecule inhibitor of both the SRC and BCR/ABL tyrosine kinases, with IC50's for the isolated kinases of 0.55 and 3.0 nM, respectively.
M1705 Erlotinib Hydrochloride EGFR/HER2 Erlotinib is an inhibitor of human EGFR tyrosine kinase (IC50 = 2 nM) and decreases EGFR autophosphorylation in tumor cells (IC50 = 20 nM).
M1709 Everolimus mTOR Everolimus (RAD001) also known as SDZ-RAD and Certican is an mTOR inhibitor with IC50 of 0.63 nM.
M1711 Febuxostat OX Receptor Febuxostat (Uloric) is a non-purine selective xanthine oxidase inhibitor with IC50 of 114 -210 nM.
M1712 FTY720 Src-bcr-Abl FTY720 (Fingolimod) is a sphingosine-1-phosphate receptor 1 receptor.
M1713 GDC-0449 Hedgehog GDC-0449 (Vismodegib) is a potent and specific hedgehog pathway inhibitor with IC50 values of 1.4 and 3.0μM for inhibition of ABCG2 and Pgp respectively.
M1714 GDC-0879 Raf GDC-0879 is a potent and selective B-Raf kinase inhibitor with an EC50 of 0.75 µM.
M1726 FG-4592 HIF FG-4592 (ASP1517) is a novel Hypoxia Inducible Factor Prolyl Hydroxylase inhibitor.
M1732 BMN673 PARP BMN673 is a potent inhibitor of poly (ADP-ribose) polymerases (PARP)-1 and -2.
M1737 MF63 PGE synthase MF63 is a selective mPGES-1 inhibitor with an IC50 of 0.9 nM and 1.3 nM for pig mPGES-1 and human mPGES-1 enzyme respectively.
M1742 Tubacin HDAC Tubacin (Tubulin Acetylation Inducer) is a highly potent and selective, reversible cell-permeable inhibitor of HDAC6 with IC50 of 0.004µM.
M1746 DAPT Gamma-secretase DAPT (GSI-IX) is a γ-secretase inhibitor with IC50 values of 115 and 200 nM for total Aβ and Aβ42 respectively.
M1749 Gefitinib EGFR/HER2 Gefitinib (ZD-1839, Iressa) is a novel potent EGFR tyrosine kinase inhibitor with an IC50 of 0.40nM.
M1753 Trichostatin A HDAC Trichostatin A (TSA) is a potent, reversible inhibitor of mammalian histone deacetylase (HDAC) with IC50 value around 20 nM.
M1757 XL-184 c-Met XL184 is a small molecule inhibits multiple receptor tyrosine kinases, specifically MET and VEGFR2 with IC50 values of 0.035 and 1.8 nM for VEGFR2 and Met respectively.
M1758 Foretinib c-Met Foretinib (XL880, GSK1363089) is a multi-targeted inhibitor of c-Met and vascular endothelial growth factor receptor 2 (VEGFR2) with IC50 value of 0.4 nM for c-MET.
M1759 GSK1120212 MEK GSK1120212 (JTP-74057) is a highly potent and selective MEK inhibitor with IC50 values to be 0.7 and 0.9 nM for MEK1 and MEK2 respectively and with long circulating half-life.
M1761 PLX4032 Raf PLX4032 (Vemurafenib, RG7204, RO5185426 and Zelboraf) is a highly selective B-Raf enzyme inhibitor with an IC50 of 44 nM against V600E-mutant BRAF.
M1763 PD-0325901 MEK PD-0325901 is a highly potent and selective MEK inhibitor with an IC50 in C26 cells of 0.33nM.
M1765 PF-2341066 c-Met PF-2341066 (Crizotinib) is a potent, orally bioavailable, ATP-competitive small-molecule inhibitor of c-Met kinase and ALK (anaplastic lymphoma kinase) with IC50 values to be 4 and 25 nM for C-Met and ALK resepectively.
M1768 Rapamycin mTOR Rapamycin (Sirolimus,Rapamune)is an inhibitor of mTOR.The mammalian target of rapamycin (mTOR) is a kinase responsible for mitogen-induced cell proliferation/survival signaling.
M1773 PI-103 PI3K PI-103 is a potent, ATP-competitive PI3K,cell-permeable,inhibitor.The IC50 values are 2, 8, 20, 26, 48, 83, 88, 150 nM for DNA-PK, p110α, mTORC1, PI3-KC2β, p110δ, mTORC2, p110β, and p110γrespectively.
M1774 PLX-4720 Raf PLX-4720 is a selective BRAFV600E inhibitor with the IC50 values of 160 nM and 130 nM for B-Raf and BRK respectively.
M1780 Vorinostat HDAC Vorinostat (SAHA, Zolinza, MK-0683) is a selective and potent histone deacetylase (HDAC) inhibitor with the IC50 value of 10 nM for HDAC-1.
M1781 SB203580 p38 MAPK SB203580 inhibits the IL-2-induced proliferation of primary human T cells, murine CT6 T cells, or BAF F7 B cells with an IC50 of 3-5 μM.
M1787 INCB18424 JAK INCB18424 is a potent inhibitor of both JAK1 and JAK2 with selectivity versus JAK3 and TYK2 (IC50 values of 2.7, 4.5, 332, and 19 nM, respectively, in biochemical assays).
M1794 SB431542 ALK SB-431542 is a potent and selective inhibitor of the transforming growth factor-β (TGF-β) type I receptor activin receptor-like kinase ALK5 (IC50 = 94 nM).
M1796 XAV939 Wnt/beta-catenin XAV939 is a potent, cell-permeable small molecule inhibitor of the Wnt/β-catenin pathway to TNKS1 and TNKS2 with IC50 values of 11 and 4 nM respectively.
M1806 PD 0332991 HCL CDK PD 0332991 is a highly specific inhibitor of cyclin-dependent kinase 4 (Cdk4) (IC50, 0.011 micromol/L) and Cdk6 (IC50, 0.016 micromol/L).
M1807 SCH727965 CDK SCH727965 (Dinaciclib) is a potent and selective CDK inhibitor with IC50 values of 1, 1, 3 and 4 nM for CDK2, CDK5, CDK1 and CDK9, respectively.
M1817 Y-27632 dihydrochloride ROCK Y-27632 is a potent, selective inhibitor of Rho-associated protein kinases (ROCK) with IC50 values of 140-220 nM for ROCK1 and ROCK2.
M1820 Tofacitinib JAK Tofacitinib (formerly tasocitinib, CP-690550) is a novel Janus Kinase 3 (JAK-3) kinase inhibitor with an IC50 value estimated at 0.2 μM.
M1825 PCI-32765 Src-bcr-Abl PCI-32765 (Ibrutinib) is a potent, selective and orally bioavailable irreversible inhibitor of BTK with IC50 value of 0.46 nM.
M1827 Sorafenib Tosylate VEGFR/PDGFR Sorafenib (BAY 43-9006) is an orally active multikinase inhibitor of tyrosine protein kinases VEGFR/PDGFR and RAF/MEK/ERK with IC50 values of 6, 22, 38 nM for Raf-1, wt BRAF and V599E mutant BRAF.
M1831 Cyclosporine A Others Cyclosporine A is a powerful immunosuppressive agent that inhibits the T-cell receptor signal transduction pathway.
M1837 MK-2206 Akt MK-2206 is a novel allosteric inhibitor of Akt with IC50 values of 8 nM, 12 nM and 65 nM for Akt1, Akt2 and Akt3, respectively.
M1838 Masitinib VEGFR/PDGFR Masitinib is a tyrosine kinase inhibitor targeting stem cell factor receptor (c-kit) and platelet-derived growth factor (PDGF) receptor.
M1839 MDV3100 CYP17 MDV3100 is an orally bioavailable, organic, non-steroidal small molecule targeting the androgen receptor (AR) with potential antineoplastic activity.
M1850 WZ4002 EGFR/HER2 WZ4002 is a novel, selective EGFR kinase inhibitor against EGFR T790M (mutation of the gatekeeper T790 residue) with IC50 of 8 nM.
M1851 WZ8040 EGFR/HER2 WZ8040 is a novel EGFR inhibitor which suppresses the growth of EGFR-T790M-containing cell lines and inhibits EGFR phosphorylation.
M1859 ALK5 Inhibitor II ALK ALK5 Inhibitor is a potent and ATP-competitive inhibitor of the TGF-β type I receptor ALK5 (IC50 values are 0.004 and 0.023 μM for ALK5 autophosphorylation and ALK5 binding respectively).
M1861 CX-4945 PKC CX-4945 (Silmitasertib) is a potent small molecule protein kinase inhibitor that selectively binds to and inhibits the enzyme casein kinase II (CK2).
M1873 LDN-193189 ALK LDN-193189 is a highly potent small molecule inhibitor of bone morphogenetic protein (BMP) type I receptors ALK2 and ALK3.
M1880 WY 14643 PPAR WY 14643 (Pirinixic Acid) is a potent and selective, peroxisome proliferator-activated receptor-α (PPARα) agonist.
M1888 Tariquidar P-gp Tariquidar (XR9576) is a selective, highly efficacious third generation P-glycoprotein (P-gp) inhibitor.
M1902 MG132 Proteasome MG132 is a specific and potent cell-permeable proteasome inhibitor (IC50 = 100 nM, Ki = 4 nM).
M1912 Nilotinib Src-bcr-Abl Nilotinib (AMN107) is a small molecule Bcr-Abl kinase inhibitor with IC50 less than 30 nM.
M1925 LY294002 PI3K LY294002 is a highly selective PI3K inhibitor with IC50 values of 0.31, 0.73, 1.06 and 6.60 μM for PI3Kβ, PI3Kα, PI3Kδ and PI3Kγ respectively.
M1966 Fulvestrant Estrogen Receptor Fulvestrant (Faslodex) is a novel estrogen receptor (ER) antagonist (IC50 = 0.29 nM).
M1969 Doxorubicin Topoisomerase Doxorubicin (trade name Adriamycin) is an anthracycline antibiotic that inhibits DNA topoisomerase II used in cancer chemotherapy.
M1970 Paclitaxel Microtubule Paclitaxel is a mitotic inhibitor with IC50 of 0.1 pM in human endothelial cells.
M1977 U0126 MEK U0126 is a potent and highly selective non-competitive inhibitor of MAPK/ERK kinase with IC50 of 72 nM for MEK1 and 58 nM for MEK2.
M1980 LY2157299 TGF-beta LY2157299 is a novel clinically relevant TBRI (ALK5 kinase) inhibitor with IC50 of 56 nM.
M1988 Dabrafenib Raf Dabrafenib (free base) (GSK2118436A) is a V600 mutant BRAF-specific inhibitor.
M1989 CHIR-99021 HCl GSK-3 CHIR-99021 HCl (CT99021) is a hydrochloride of CHIR-99021, with IC50 of 10 nM and 6.7 nM for GSK-3α and GSK-3β, respectively.
M1992 2-Methoxyestradiol HIF 2-Methoxyestradiol (2ME2) is a natural metabolite of estradiol acts via an estrogen receptor-independent mechanism.
M2008 ICG-001 Wnt/beta-catenin ICG-001 is a novel small molecule inhibitor of TCF/beta-catenin-mediated transcription.
M2017 ABT-199 Bcl-2 ABT-199 is a highly potent, orally bioavailable and BCL-2 inhibitor.
M2023 R428 Axl R428 is a potent and selective small-molecule inhibitor of Axl kinase with IC50 of 14 nM.
M2031 SU5416 VEGFR/PDGFR SU5416 is a novel small molecule multi-targeted kinase inhibitor of VEGF receptors, c-kit and FLT3.
M2048 Sumatriptan succinate 5-HT Receptor Sumatriptan succinate is a 5-HT1 serotonin receptor agonist.
M2071 ONX-0914 Proteasome ONX-0914 (PR-957) is a potent and selective immunoproteasome inhibitor.
M2075 LDK378 ALK LDK378 is a highly selective, orally bioavailable ALK inhibitor with IC50 of 0.15 nM.
M2076 SP600125 JNK SP600125 is a novel and selective inhibitor of c-Jun N-terminal kinase (JNK), inhibited phosphorylation of c-Jun with an IC50 of 5-10 microM.
M2078 SAR131675 VEGFR/PDGFR SAR131675 is a potent and selective VEGFR-3 inhibitor with IC50 of 20 nM.
M2080 INCB28060 c-Met INCB28060 is a novel inhibitor of c-MET kinase with IC50 of 0.13 nM.
M2084 SCH772984 ERK SCH772984 is a novel and selective inhibitor of ERK1/2 with IC50 of 4 nM and 1 nM, respectively.
M2111 CUDC-907 HDAC CUDC-907 is a potent, orally-available small molecule dual PI3K and HDAC inhibitor.
M2129 Temozolomide Autophagy Temozolomide is an oral DNA methylating, chemotherapeutic agent.
M2143 MK-1775 Wee1 MK-1775 is a potent and selective small molecule Wee1 kinase inhibitor with IC50 of 5.2 nM.
M2167 (+)-JQ1 Epigenetic Reader Domain (+)-JQ1 is a potent, high affinity, selective BET bromodomain inhibitor.
M2185 Nutlin-3 Mdm2 Nutlin-3 is a selective MDM2 (mouse double minute 2) antagonist with IC50 of 90 nM.
M2206 TH-302 CYP17 TH-302 is a highly potent and selective hypoxia-activated procompound targeting hypoxic regions of solid tumors with IC50 of 19 nM.
M2223 Cisplatin DNA/RNA Synthesis Cisplatin is a potent anticancer agent that blocks DNA synthesis.
M2238 Dorsomorphin dihydrochloride AMPK Dorsomorphin (BML-275) dihydrochloride is a potent and selective AMPK inhibitor with Ki value of 109 nM.
M2288 Carboplatin DNA/RNA Synthesis Carboplatin is a DNA synthesis inhibitor by binding to DNA and interfering with the cell's repair mechanism.
M2296 3-Methyladenine PI3K 3-Methyladenine (3-MA) is a selective PI3K inhibitor for Vps34 and PI3Kγ with IC50 of 25 μM and 60 μM, respectively.
M2297 CPI-613 Dehydrogenase CPI-613 inhibits mitochondrial enzymes pyruvate dehydrogenase (PDH) and α-ketoglutarate dehydrogenase.
M2352 10058-F4 c-Myc 10058-F4 is a c-Myc inhibitor that specificallly inhibits the c-Myc-Max interaction and prevents transactivation of c-Myc target gene expression.
M2424 AZD9291 EGFR/HER2 AZD9291 is an oral, irreversible, and mutant-selective EGFR inhibitor with IC50 of 12.92, 11.44 and 493.8 nM for Exon 19 deletion EGFR, L858R/T790M EGFR, and WT EGFR, respectively.
M2448 GANT61 Hedgehog GANT61 is an inhibitor for GLI1 as well as GLI2-induced transcription, inhibits hedgehog with IC50 of 5 μM.
M3026 Sorafenib Raf Sorafenib is a multikinase inhibitor of Raf-1, B-Raf and VEGFR-2 with IC50 of 6 nM, 22 nM and 90 nM, respectively.
M3115 VE-822 ATM/ATR VE-822 is an ATR inhibitor with IC50 of 19 nM.
M3417 Clozapine 5-HT Receptor Clozapine is a potent 5-HT1C receptor antagonist with an IC50 of 110 nM for 5-HT-stimulated phosphoinositide hydrolysis.
M3517 Lapatinib EGFR/HER2 Lapatinib, used in the form of Lapatinib ditosylate, is a potent EGFR and ErbB2 inhibitor with IC50 of 10.8 and 9.2 nM, respectively.
M3935 Digoxin Others Digoxin is widely used in the treatment of various heart conditions, namely atrial fibrillation, atrial flutter and sometimes heart failure that cannot be controlled by other medication.
M4837 Captisol Others Captisol is a unique reproducible mixture of polyanionic β-cyclodextrin derivatives in which a sodium sulfonate salt is tethered to the lipophilic cyclodextrin cavity by a butyl ether group, or sulfobutylether (SBE).
M5099 AZD-9291 (Mesylate) EGFR/HER2 AZD-9291 is a potent and selective mutated forms EGFR inhibitor(Exon 19 deletion EGFR IC50=12.92 nM, L858R/T790M EGFR IC50= 11.44 nM, wild type EGFR IC50= 493.8 nM).

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