Free shipping on all orders over $ 500


Cat. No. M5211
ZM241385 Structure


Size Price Availability Quantity
10mg USD 105 In stock
25mg USD 230 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
Biological Activity

ZM241385 is a novel non-xanthine adenosine receptor antagonist with selectivity for the A2a receptor subtype. ZM-241385 significantly blunts the hypotensive effects of CCPA and NECA without altering the bradycardia induced by these agonists. It blocks the infarct size-reducing effects(cardioprotective effects) of this two distinct adenosine receptor agonists.

In vitro: ZM-241385 exhibits high potency for A2a receptor-mediated effects versus A1 receptor-mediated effects. A2AR agonist CGS21680 dramatically up-regulated A2AR mRNA; this response was reversed by concurrent exposure to ZM241385.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 337.34
Formula C16H15N7O2
CAS Number 139180-30-6
Purity 98.77%
Solubility DMSO 65 mg/mL
Storage at -20°C

The A2a/A2b receptor antagonist ZM-241385 blocks the cardioprotective effect of adenosine agonist pretreatment in in vivo rat myocardium.
Lasley RD, et al. Am J Physiol Heart Circ Physiol. 2007 Jan;292(1):H426-31. PMID: 16980350.

Related Adenosine Receptor Products

AZD4635 is a novel adenosine 2A receptor (A2AR) inhibitor with a Ki of 1.7 nM.


CPI-444 is a potent and selective inhibitor of A2A receptor (A2AR) induces antitumor responses.


Regadenoson is an A2A adenosine receptor agonist that is a coronary vasodilator that is commonly used in pharmacologic stress testing.


Pentostatin (Deoxycoformycin) is an irreversible inhibitor of adenosine deaminase (Ki = 2.5 pM).

CGS 21680

CGS 21680 is a selective adenosine receptor agonist for A2A and A3 with Ki of 15 ng/mL and 37 ng/mL, respectively.

Abmole Inhibitor Catalog 2017

Keywords: ZM241385, ZM-241385 supplier, Adenosine Receptor, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2017 AbMole BioScience. All Rights Reserved.