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ZM 306416

Cat. No. M3139
ZM 306416 Structure
Synonym:

CB 676475

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
10mg USD 120 In stock
50mg USD 460 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

ZM 306416 is a VEGFR (Flt and KDR) inhibitor for VEGFR1 with IC50 of 0.33 μM, but also found to inhibit EGFR with IC50 of <10 nM.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 333.74
Formula C16H13ClFN3O2
CAS Number 690206-97-4
Purity >99%
Solubility DMSO 50 mg/mL
Storage at -20°C
Customer Product Validations & Biological Datas
Source J Biomol Screen (2012). Figure 6. ZM 306416
Method Assessment of the anti-proliferative effects of hits against a panel of established cell lines
Cell Lines EGFR cell lines A549 and H2030
Concentrations 10 μM
Incubation Time -
Results Confirming the newly identified inhibitory activity of ZM-306416 toward EGFR, this compound induced selective anti-proliferative effect toward the EGFR addicted NSCLC cell lines H3255 and HCC4011, while sparing the wild type EGFR cell lines A549 and H2030.
Rating
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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: ZM 306416, CB 676475 supplier, VEGFR/PDGFR, inhibitors

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