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Zimelidine dihydrochloride

Cat. No. M8865
Zimelidine dihydrochloride Structure
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Quality Control & Documentation
Biological Activity

Serotonin transport blocker; Antidepressant compounds.

Chemical Information
Molecular Weight 390.15
Formula C16H17BrN2 · 2HCl
CAS Number 61129-30-4
Solubility (25°C) 0.1 M HCl: 45 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] H Nyqvist, et al. Change in surface area of zimeldine dihydrochloride hydrate on storage

[2] K Schaffler, et al. Vigilance behavior in interaction of the serotonin-selective antidepressant zimelidine and parenterally administered ethanol

[3] P H Redfern, et al. The effect of antidepressant drugs on 24-hour rhythms of tryptophan metabolism in the rat

[4] A Kruszewska, et al. Different effects of zimelidine on the reinforcing properties of d-amphetamine and morphine on conditioned place preference in rats

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