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ZD 7114 hydrochloride

Cat. No. M8872
ZD 7114 hydrochloride Structure
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5mg USD 350  USD350 Custom Synthesis
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Quality Control & Documentation
Biological Activity

ZD 7114 is a selective β3 adrenergic receptor agonist. β3 adrenoceptors are expressed in adipose tissue and smooth muscle.

Chemical Information
Molecular Weight 454.94
Formula C22H30N2O6 · HCl
CAS Number 129689-28-7
Solubility (25°C) Water: ≥20 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Jillian G Baker. Evidence for a secondary state of the human beta3-adrenoceptor

[2] Sandeep Rathi, et al. Functional and molecular characterization of beta-adrenoceptors in the internal anal sphincter

[3] B Buemann, et al. Effects of the two beta3-agonists, ZD7114 and ZD2079 on 24 hour energy expenditure and respiratory quotient in obese subjects

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