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Zatebradine

Cat. No. M6063
Zatebradine Structure
Size Price Availability Quantity
10mg USD 130 In stock
50mg USD 500 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Zatebradine(UL-FS49) is a potent HCN channels antagonist, which decreased the heartbeat in a reversible manner; 92% inhibition of the hHCN1-mediated current at 10 uM.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 456.57
Formula C26H36N2O5
CAS Number 85175-67-3
Purity >99%
Solubility 10 mM in DMSO
Storage at -20°C
References

Effects of zatebradine and propranolol on canine ischemia and reperfusion-induced arrhythmias.
Naito H, et al. Eur J Pharmacol. 2000 Jan 28;388(2):171-6. PMID: 10666509.

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  Catalog
Abmole Inhibitor Catalog 2017




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