Potent inhibitor, in vivo and in vitro, of mammalian, fungal and Saccharomyces cervisiae squalene synthase. Squalene synthase is the first committed enzyme in sterol synthesis, catalyzing the reductive condensation of farnesyl pyrophosphate to form squalene. As a squalene synthase inhibitor, zaragozic acid produces lower plasma cholesterol levels in primates. Treatment of rats with zaragozic acid A caused an increase in hepatic low density lipoprotein (LDL) receptor mRNA levels.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Calf thymus DNA
Calf thymus DNA is high quality double-stranded template DNA isolated from the thymus of male and female calves.
Cremophor EL is a mixture of polyoxyethylated triglycerides, by reacting castor oil with ethylene oxide, that acts as a nonionic surfactant and serves as a formulation vehicle for poorly-water soluble pharmacological agents.
PEG300 is a neutral and biocompatible hydrophilic polymer.
MnTMPyP Pentachloride is a superoxide dismutase (SOD) mimetic and peroxynitrite scavenger.
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