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Z-WEHD-FMK

Cat. No. M13538
Z-WEHD-FMK Structure
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Biological Activity

Z-WEHD-FMK is a potent, cell-permeable and irreversible caspase-1/5 inhibitor. Z-WEHD-FMK also exhibits a robust inhibitory effect on cathepsin B activity (IC50=6 μM). Z-WEHD-FMK can be used to investigate cells for evidence of apoptosis.

Chemical Information
Molecular Weight 763.77
CAS Number 210345-00-9
Solubility (25°C) DMSO 90 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Maxime-Alexandre Ferko, et al. PLoS One. Effects of metal ions on caspase-1 activation and interleukin-1β release in murine bone marrow-derived macrophages

[2] Renqing Wang, et al. Lab Invest. Activation of NLRP3 inflammasomes contributes to hyperhomocysteinemia-aggravated inflammation and atherosclerosis in apoE-deficient mice

[3] Nazario Rubio, et al. J Neurovirol. Overexpression of caspase 1 in apoptosis-resistant astrocytes infected with the BeAn Theiler's virus

[4] Salik Hussain, et al. Part Fibre Toxicol. Inflammasome activation in airway epithelial cells after multi-walled carbon nanotube exposure mediates a profibrotic response in lung fibroblasts

[5] Min-Jung Kim, et al. J Immunol. Active caspase-1-mediated secretion of retinoic acid inducible gene-I

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  Catalog
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Keywords: Z-WEHD-FMK supplier, Caspase, inhibitors, activators


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