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Z-LEHD-FMK

Cat. No. M3138
Z-LEHD-FMK Structure
Synonym:

Caspase-9 Inhibitor

Size Price Availability
1mg USD 210 4-7 Days
10mg USD 1220 4-7 Days
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Z-LEHD-FMK is a specific, irreversible Caspase-9 inhibitor.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 690.72
Formula C32H43FN6O10
CAS Number 210345-04-3
Purity >98%
Solubility DMSO
Storage at -20°C
Related Caspase Products
CA-074

CA-074 is a potent inhibitor of cathepsin B with a Ki of 2 to 5 nM.

Z-YVAD-FMK

Z-YVAD-FMK is a synthetic peptide that irreversibly inhibits activity of caspase-1. The inhibitor is designed as a methyl ester to facilitate cell permeability. The product can be used for both in vitro and in vivo studies.

Z-LEED-FMK

Z-LEED-FMK is caspase-13 inhibitor.

Z-VAD(OH)-FMK

Z-VAD-FMK (Caspase Inhibitor VI) is an irreversible pan-caspase inhibitor.

BOC-D-FMK

Boc-D-FMK is a cell-permeable, irreversible and broad spectrum caspase inhibitor; inhibits apoptosis stimulated by TNF-α with an IC50 of 39 µM.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Z-LEHD-FMK, Caspase-9 Inhibitor supplier, Caspase, inhibitors

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