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Z-LEED-FMK

Cat. No. M6232
Z-LEED-FMK Structure
Size Price Availability Quantity
5mg USD 450 In stock
10mg USD 820 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Z-LEED-FMK is caspase-13 inhibitor.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 696.72
Formula C32H45FN4O12
CAS Number
Purity >98%
Solubility 10 mM in DMSO
Storage at -20°C
References

Bovine herpesvirus 4 induces apoptosis of human carcinoma cell lines in vitro and in vivo.
Gillet L, et al. Cancer Res. 2005 Oct 15;65(20):9463-72. PMID: 16230410.

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Z-YVAD-FMK

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Z-VAD(OH)-FMK

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BOC-D-FMK

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Z-LEED-FMK supplier, Caspase, inhibitors

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