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Cat. No. M3136
Z-IETD-FMK Structure

Caspase-8 Inhibitor

Size Price Availability Quantity
1mg USD 160 In stock
10mg USD 620 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Z-IETD-FMK is a specific Caspase-8 inhibitor.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 654.68
Formula C30H43FN4O11
CAS Number 210344-98-2
Purity >99%
Solubility DMSO
Storage at -20°C
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Abmole Inhibitor Catalog 2017

Keywords: Z-IETD-FMK, Caspase-8 Inhibitor supplier, Caspase, inhibitors

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