Z-IETD-FMK is a specific Caspase-8 inhibitor.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Related Caspase Products|
Boc-D-FMK is a cell-permeable, irreversible and broad spectrum caspase inhibitor; inhibits apoptosis stimulated by TNF-α with an IC50 of 39 µM.
Emricasan is a potent irreversible pan-caspase inhibitor.
NQDI-1 is a selective inhibitor of ASK1 with a Ki of 500 nM.
VX-765 is a potent and selective inhibitor of caspase-1 with Ki of 0.8 nM.
Betulinic acid is a pentacyclic triterpene which selectively induces apoptosis in tumor cells.It is a inhibitor of HIV-1 with EC50 of 1.4 μM.
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