Z-IETD-FMK is a specific Caspase-8 inhibitor.
|Source||Mar Drugs (2018). Figure 6. Z-IETD-FMK|
|Cell Lines||MG63 cells|
|Incubation Time||24 h|
|Results||These data indicated that MSP-4 induced cytotoxicity and caspase-dependent apoptosis, but pretreatment with Z-IETD-FMK (caspase-8 inhibitor) or Z-LEHD-FMK (caspase-9 inhibitor) sharply suppressed the cells’ cytotoxicity and caspase expression in Western blots.|
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
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