Free shipping on all orders over $ 500

Z-IETD-FMK

Cat. No. M3136
Z-IETD-FMK Structure
Synonym:

Caspase-8 Inhibitor

Size Price Availability Quantity
1mg USD 140  USD140 In stock
5mg USD 315  USD315 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Z-IETD-FMK is a specific Caspase-8 inhibitor.

Customer Product Validations & Biological Datas
Source Mar Drugs (2018). Figure 6. Z-IETD-FMK
Method MTT assay
Cell Lines MG63 cells
Concentrations 10 μM
Incubation Time 24 h
Results These data indicated that MSP-4 induced cytotoxicity and caspase-dependent apoptosis, but pretreatment with Z-IETD-FMK (caspase-8 inhibitor) or Z-LEHD-FMK (caspase-9 inhibitor) sharply suppressed the cells’ cytotoxicity and caspase expression in Western blots.
Chemical Information
Molecular Weight 654.68
Formula C30H43FN4O11
CAS Number 210344-98-2
Solubility (25°C) DMSO ≥ 66 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Y Niu, et al. The application of apoptotic inhibitor in apoptotic pathways of MII stage porcine oocytes after vitrification

[2] Wei Chi, et al. HMGB1 promotes the activation of NLRP3 and caspase-8 inflammasomes via NF-κB pathway in acute glaucoma

[3] C P Lawrence, et al. Suppression of human T cell proliferation by the caspase inhibitors, z-VAD-FMK and z-IETD-FMK is independent of their caspase inhibition properties

[4] Andrew S Cowburn, et al. z-VAD-fmk augmentation of TNF alpha-stimulated neutrophil apoptosis is compound specific and does not involve the generation of reactive oxygen species

[5] N Ozoren, et al. The caspase 9 inhibitor Z-LEHD-FMK protects human liver cells while permitting death of cancer cells exposed to tumor necrosis factor-related apoptosis-inducing ligand

Related Caspase Products
TC11

TC11 is a phenylphthalimide derivative and an activator of caspase-9 and CDK1, as well as a degrader of MCL1.TC11 is structurally related to immunomodulatory active molecules. During prolonged mitotic blockade, TC11 induces MCL1 degradation and leads to apoptotic death.

Ac-Ile-Glu-Thr-Asp-pNA

Ac-Ile-Glu-Thr-Asp-pNA is a substrate for caspase-8.

Z-DEVD-AFC

Z-DEVD-AFC is a cell-permeant substrate for caspase-3, which causes a shift in fluorescence uponcleavage of the AFC fluorophore.

Ac-IETD-AFC

Ac-IETD-AFC is a fluorogenic substrate of caspase-8, caspase-3, caspase-10, and granzyme B.

Z-VDVAD-FMK

Z-VDVAD-FMK is a special inhibitor of caspase-2.

  Catalog
Abmole Inhibitor Catalog




Keywords: Z-IETD-FMK, Caspase-8 Inhibitor supplier, Caspase, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.