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Yohimbine-Hydrochloride

Cat. No. M4593
Yohimbine-Hydrochloride Structure
Synonym:

YHB Hydrochloride

Size Price Availability Quantity
500mg USD 45  USD45 In stock
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Quality Control & Documentation
Biological Activity

Yohimbine hydrochloride is an α2-adrenergic receptor antagonist.

Chemical Information
Molecular Weight 390.9
Formula C21H26N2O3.HCl
CAS Number 65-19-0
Solubility (25°C) Water 10 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Yani Zhao, et al. Yohimbine hydrochloride inhibits benign prostatic hyperplasia by downregulating steroid 5α-reductase type 2

[2] Nevio Cimolai, et al. Yohimbine use for physical enhancement and its potential toxicity

[3] Sergej M Ostojic. Yohimbine: the effects on body composition and exercise performance in soccer players

[4] S W Tam, et al. Yohimbine: a clinical review

[5] M Shannon, et al. Yohimbine

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