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YM 90K hydrochloride

Cat. No. M3791
YM 90K hydrochloride Structure
Size Price Availability Quantity
5mg USD 160 In stock
10mg USD 240 In stock
50mg USD 820 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

YM 90K hydrochloride delays neuronal death in a global ischemia model and cerebral infarction in a focal ischemia model following postischemic administration. The novel AMPA receptor antagonist YM90K was effective in the treatment of focal cerebral ischaemic lesions. Activation of AMPA receptor may play a key role in the development of cerebral infarct in the early phase of ischaemia in rats. YM90K is a potent and competitive antagonist for AMPA receptors and the apparent affinity of competitive antagonists was reduced by cyclothiazide. Cyclothiazide can affect the interaction between receptors and both agonists and antagonists, suggesting that it might allosterically alter the affinity of agonists and competitive antagonists for their binding site on the AMPA receptor complex. YM 90K may be useful for the treatment of acute epileptic conditions such as status epilepticus. Moreover, it might prevent pathological neuronal plasticity resulting from status epilepticus, since it shows an antiepileptogenic effect and protects hippocampal neurons during kainate-induced generalized seizures.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 309.67
Formula C11H7N5O4.HCl
CAS Number 154164-30-4
Purity >99%
Solubility DMSO
Storage at -20°C
References

A potent AMPA/kainate receptor antagonist, YM90K, attenuates the loss of N-acetylaspartate in the hippocampal CA1 area after transient unilateral forebrain ischemia in gerbils.
Nakano M, et al. Life Sci. 2001 Sep 14;69(17):1983-90. PMID: 11589513.

Effects of YM90K, a selective AMPA receptor antagonist, on amygdala-kindling and long-term hippocampal potentiation in the rat.
Kodama M, et al. Eur J Pharmacol. 1999 Jun 11;374(1):11-9. PMID: 10422635.

Neuroprotective effect of a novel AMPA receptor antagonist, YM90K, in rat focal cerebral ischaemia.
Umemura K, et al. Brain Res. 1997 Oct 31;773(1-2):61-5. PMID: 9409705.

Characterization of YM90K, a selective and potent antagonist of AMPA receptors, in rat cortical mRNA-injected Xenopus oocytes.
Okada M, et al. Eur J Pharmacol. 1996 Aug 15;309(3):299-306. PMID: 8874154.

Characterization of YM90K, a selective and potent antagonist of AMPA receptors, in rat cortical mRNA-injected Xenopus oocytes.
Okada M, et al. Eur J Pharmacol. 1996 Aug 15;309(3):299-306. PMID: 8874154.

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