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YK 3-237

Cat. No. M7500
YK 3-237 Structure
Size Price Availability Quantity
5mg USD 70  USD70 In stock
10mg USD 110  USD110 In stock
25mg USD 230  USD230 In stock
50mg USD 390  USD390 In stock
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Quality Control & Documentation
Biological Activity

YK 3-237 is a sIRT1 activator. Inhibits proliferation of breast cancer cell lines expressing mutant p53. Induces G2/M cell cycle arrest and apoptosis in triple negative breast cancer cells (TNBCs) in vitro.

Chemical Information
Molecular Weight 372.18
Formula C19H21BO7
CAS Number 1215281-19-8
Solubility (25°C) DMSO 37.22 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Fong, et al. Cancer Res. SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularisation, and growth of multiple tumor types.

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Keywords: YK 3-237 supplier, Sirtuin, inhibitors, activators


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