Free shipping on all orders over $ 500

XL413

Cat. No. M3641
XL413 Structure
Synonym:

BMS-863233

Size Price Availability Quantity
5mg USD 135 In stock
10mg USD 190 In stock
50mg USD 580 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

XL413 inhibits the cell proliferation. XL413 decreases cell viability and elicits the caspase 3/7 activity in Colo-205 cells. XL413 results in modified S phase progression that subsequently leads to apoptotic cell death. XL413, at the 3 mg/kg dose, causes 70% inhibition of phosphorylated MCM2, and causes significant tumor growth regression at the 100 mg/kg dose.

Protocol
Cell Experiment
Cell lines Colo-205 cells
Preparation method Using BrdU incorporation assay to measure the cell proliferation , and by Cell Titer–Glo kits to assay viability .
Concentrations ~10 μM
Incubation time 24 hours
Animal Experiment
Animal models Mice bearing Colo-205 xenografts
Formulation
Dosages ~100 mg/kg
Administration p.o.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 326.18
Formula C14H13Cl2N3O2
CAS Number 1169562-71-3
Purity >98%
Solubility DMSO
Storage at -20°C
References

Discovery of XL413, a potent and selective CDC7 inhibitor.
Koltun ES, et al. Bioorg Med Chem Lett. 2012 Jun 1;22(11):3727-31. PMID: 22560567.

Related CDK Products
THZ2

THZ2 (an analog of THZ1) is a potent and selective CDK7 inhibitor which overcomes the instability of THZ1 in vivo (IC50s: CDK7=13.9 nM; TNBC cells=10 nM).

LY-3177833

LY-3177833 is a potent and selective inhibitor of CDC7 with IC50 of 3.3 nM.

Voruciclib

Voruciclib (P1446A-05) is a protein kinase inhibitor specific for the cyclin-dependent kinase 4 (CDK4) with IC50s of 90nM, 25nM, and 22nM for CDK4-CyclinD1, CDK1-Cyclin B, and CDK9-Cyclin T, respectively.

CVT-313

CVT-313 is a potent and selective inhibitor of CDK2 that prevents neointimal proliferation, which has an IC50 of 0.5 microM in vitro.

ON123300

ON123300 is a potent inhibitor of CDK4, with an IC50 of 3.8 nM, with little inhibitory activity against CDKs 1,2,5 and 8.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: XL413, BMS-863233 supplier, CDK, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2017 AbMole BioScience. All Rights Reserved.