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X80

Cat. No. M8860
X80 Structure
Size Price Availability
5mg USD 295  USD295 Custom Synthesis
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Quality Control & Documentation
Biological Activity

X80 is an inhibitor of xeroderma pigmentosum group A protein (XPA protein) required for the removal of all types of DNA lesions repaired by nucleotide excision repair Including both transcription coupled and global genomic nucleotide excision repair.

Chemical Information
Molecular Weight 450.83
Formula C23H15ClN2O6
CAS Number 292065-64-6
Solubility (25°C) DMSO: ≥40 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Congmin Xu, et al. Effect of SRB and Applied Potential on Stress Corrosion Behavior of X80 Steel in High-pH Soil Simulated Solution

[2] Zhuowei Tan, et al. Corrosion behavior of X80 pipeline steel local defect pits under static liquid film

[3] Tiansui Zhang, et al. Crevice corrosion of X80 carbon steel induced by sulfate reducing bacteria in simulated seawater

[4] Yan-Yu Cui, et al. Study on corrosion behavior of X80 steel under stripping coating by sulfate reducing bacteria

[5] Bo Liu, et al. Study of biofilm-influenced corrosion on X80 pipeline steel by a nitrate-reducing bacterium, Bacillus cereus, in artificial Beijing soil

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