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WNK463

Cat. No. M11214
WNK463  Structure
Size Price Availability Quantity
5mg USD 160  USD160 In stock
10mg USD 240  USD240 In stock
25mg USD 460  USD460 In stock
50mg USD 740  USD740 In stock
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Quality Control & Documentation
Biological Activity

WNK463 is an oral WNK kinase inhibitor for WNK1, WNK2, WNK3, and WNK4 IC50 The values are 5 nM, 1 nM, 6 nM, and 9 nM, respectively.

Chemical Information
Molecular Weight 463.46
Formula C21H24F3N7O2
CAS Number 2012607-27-9
Solubility (25°C) DMSO ≥ 60 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Sasha Z Prisco, et al. JACC Basic Transl Sci. With No Lysine Kinase 1 Promotes Metabolic Derangements and RV Dysfunction in Pulmonary Arterial Hypertension

[2] Lindsey Mayes-Hopfinger, et al. Nat Commun. Chloride sensing by WNK1 regulates NLRP3 inflammasome activation and pyroptosis

[3] Viktor N Tomilin, et al. Cells. With-No-Lysine Kinase 1 (WNK1) Augments TRPV4 Function in the Aldosterone-Sensitive Distal Nephron

[4] Tian-Qiong Lang, et al. J Asian Nat Prod Res. Characterization of chemical components with diuretic potential from Pyrrosia petiolosa

[5] Nisha A Jonniya, et al. J Biomol Struct Dyn. Investigating specificity of the anti-hypertensive inhibitor WNK463 against With-No-Lysine kinase family isoforms via multiscale simulations

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Keywords: WNK463 supplier, Serine/Threonine Protease, inhibitors, activators


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