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WHI-P97

Cat. No. M9035
WHI-P97 Structure
Size Price Availability
10mg USD 265 4-7 Days
50mg USD 790 4-7 Days
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

WHI-P97 effectively inhibited the in vitro invasiveness of EGFR-positive human cancer cells in a concentration-dependent manner. WHI-P97 was very well tolerated in mice, with no signs of toxicity at dose levels ranging from 5 microg/kg to 50 mg/kg, and LD(10) was not reached at a 50 mg/kg dose level when administered as a single i. p. or i.v. bolus dose.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 455.1
Formula C16H13Br2N3O3
CAS Number 211555-05-4
Purity >98%
Solubility DMSO 10 mM
Storage at -20°C
References

Thrombin induces expression of cytokine-induced SH2 protein (CIS) in rat brain astrocytes: involvement of phospholipase A2, cyclooxygenase, and lipoxygenase.
Ji KA, et al. Glia. 2004 Nov 1;48(2):102-11. PMID: 15378659.

Tyrosine kinase inhibitors: a new approach for asthma.
Wong WS, et al. Biochim Biophys Acta. 2004 Mar 11;1697(1-2):53-69. PMID: 15023350.

Structure-based design of novel anticancer agents.
Uckun FM, et al. Curr Cancer Drug Targets. 2001 May;1(1):59-71. PMID: 12188892.

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  Catalog
Abmole Inhibitor Catalog 2017




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