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WH-4-023

Cat. No. M3676
WH-4-023 Structure
Size Price Availability Quantity
5mg USD 80 In stock
10mg USD 125 In stock
50mg USD 380 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

WH-4-023 is a potent and orally active Lck/Src inhibitor with IC50 of 2 nM and 6 nM. WH-4-023 has little inhibition on p38α and KDR.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 568.67
Formula C32H36N6O4
CAS Number 837422-57-8
Purity >99%
Solubility DMSO 10 mg/mL
Storage at -20°C
References

Novel 2-aminopyrimidine carbamates as potent and orally active inhibitors of Lck: synthesis, SAR, and in vivo antiinflammatory activity.
Martin MW, et al. J Med Chem. 2006 Aug 10;49(16):4981-91. PMID: 16884310.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: WH-4-023 supplier, Src-bcr-Abl, inhibitors

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