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WAY-262611

Cat. No. M3886
WAY-262611 Structure
Size Price Availability Quantity
10mg USD 130 In stock
50mg USD 420 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

WAY262611 was able to enhance trabecular bone formation rate in the tibia of OVX rats following oral administration. WAY-262611 is acting via the Wnt β-catenin pathway and most likely through inhibition of Dkk-1.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 318.42
Formula C20H22N4
CAS Number 1123231-07-1
Purity >99%
Solubility DMSO 40 mg/mL
Storage at -20°C
References

(1-(4-(Naphthalen-2-yl)pyrimidin-2-yl)piperidin-4-yl)methanamine: a wingless beta-catenin agonist that increases bone formation rate.
Pelletier JC, et al. J Med Chem. 2009 Nov 26;52(22):6962-5. PMID: 19856966.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: WAY-262611 supplier, Wnt/beta-catenin, inhibitors

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