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Warfarin

Cat. No. M6059
Warfarin Structure
Synonym:

Athrombine K, Coumadin, Coumafene, WARF 42, Zoocoumarin

Size Price Availability Quantity
100mg USD 60 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Warfarin is one of the most widely used anticoagulant drugs worldwide, used in the prevention of thrombosis and thromboembolism, the formation of blood clots in the blood vessels and their migration elsewhere in the body.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 308.33
Formula C19H16O4
CAS Number 81-81-2
Purity >99%
Solubility 10 mM in DMSO
Storage at -20°C
References

Warfarin Metabolites in Patients Following Cardiac Valve Implantation: A Contribution of Clinical and Genetic Factors.
Bryk A, et al. Cardiovasc Drugs Ther. 2015 Jun;29(3):257-64. PMID: 25986145.

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Keywords: Warfarin, Athrombine K, Coumadin, Coumafene, WARF 42, Zoocoumarin supplier, inhibitors

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