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W146

Cat. No. M3129
W146 Structure
Synonym:

W-146; W 146

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1mg USD 300  USD300 Out of stock
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Quality Control & Documentation
Biological Activity

W146 is a potent S1P1 selective antagonist with Ki of 18 nM.

Chemical Information
Molecular Weight 342.37
Formula C16H27N2O4P
CAS Number 909725-61-7
Solubility (25°C) DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Qiufen Zhang, et al. Whole genome analysis of an MDR Beijing/W strain of Mycobacterium tuberculosis with large genomic deletions associated with resistance to isoniazid

[2] Sung Eun Kim, et al. The Role of Sphingosine-1-Phosphate in Adipogenesis of Graves' Orbitopathy

[3] Jingjing Liu, et al. 3-amino-4-(3-hexylphenylamino)-4-oxobutyl phosphonic acid (W146), a Selective Antagonist of Sphingosine-1-phospahte Receptor Subtype 1, Enhances AMD3100-stimulated Mobilization of Hematopoietic Stem Progenitor Cells in Animals

[4] Aravind Mohandas, et al. FDG PET/CT in the management of nasopharyngeal carcinoma

[5] Gema Tarrasn, et al. The sphingosine-1-phosphate receptor-1 antagonist, W146, causes early and short-lasting peripheral blood lymphopenia in mice

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  Catalog
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Keywords: W146, W-146; W 146 supplier, S1P Receptor, inhibitors, activators


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