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VUF11207 fumarate

Cat. No. M9751
VUF11207 fumarate Structure
Size Price Availability Quantity
2mg USD 65  USD65 In stock
5mg USD 100  USD100 In stock
10mg USD 170  USD170 In stock
25mg USD 350  USD350 In stock
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Quality Control & Documentation
Biological Activity

VUF11207 fumarate is a CXCR7 agonist and a high-potency CXCR7 ligand (pKi=8.1). VUF11207 fumarate induces recruitment of β-arrestin2 (pEC50=8.8) and subsequent internalization (pEC50=7.9) of CXCR7.

Chemical Information
Molecular Weight 586.65
Formula C31H39FN2O8
CAS Number 1785665-61-3
Solubility (25°C) DMSO ≥ 100 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Maikel Wijtmans, et al. Eur J Med Chem. Synthesis, modeling and functional activity of substituted styrene-amides as small-molecule CXCR7 agonists

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