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VU-0155069

Cat. No. M8927
VU-0155069 Structure
Size Price Availability Quantity
10mg USD 260 In stock
50mg USD 1000 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

VU-0155069 is a potent and selective phospholipase D1 (PLD1) inhibitor with IC50 values of 46 and 933 nM for PLD1 and PLD2, respectively. VU0155069 inhibits migration of human and mouse breast cancer cell lines in transwell assays. VU0155069 significantly decreases invasive migration in breast cancer cell lines (MDA-231, 4T1 and PMT).

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 462.97
Formula C26H27ClN4O2
CAS Number 1130067-06-9
Purity >98%
Solubility DMSO: ≥ 20 mg/mL
Ethanol: ≥ 20 mg/mL
Storage at -20°C
References

PEA-15 potentiates H-Ras-mediated epithelial cell transformation through phospholipase D.
Sulzmaier FJ, et al. Oncogene. 2012 Jul 26;31(30):3547-60. PMID: 22105357.

Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness.
Scott SA, et al. Nat Chem Biol. 2009 Feb;5(2):108-17. PMID: 19136975.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: VU-0155069 supplier, Phospholipase, inhibitors

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