VS-5584 (SB2343) is a potent and selective dual PI3K/mTOR inhibitor for mTOR, PI3Kα/β/δ/γ with IC50 of 3.4 nM and 2.6-21 nM, respectively.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Solubility||DMSO 60 mg/mL|
|Source||Oncotarget (2017). Figure 1. VS-5584|
|Cell Lines||PDAC cell lines|
|Incubation Time||48 h|
|Results||In BxPC-3, CFPAC-1, and HPAC cells, VS-5584 treatment decreased the percentage of cells in the S and G2/M cell cycle phases and increased the percentage of G0/G1 cells|
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