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VS-5584

Cat. No. M2567
VS-5584 Structure
Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
5mg USD 95 In stock
10mg USD 130 In stock
50mg USD 420 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

VS-5584 (SB2343) is a potent and selective dual PI3K/mTOR inhibitor for mTOR, PI3Kα/β/δ/γ with IC50 of 3.4 nM and 2.6-21 nM, respectively.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 354.41
Formula C17H22N8O
CAS Number 1246560-33-7
Purity >99%
Solubility DMSO 60 mg/mL
Storage at -20°C
Customer Product Validations & Biological Datas
Source Oncotarget (2017). Figure 1. VS-5584
Method MTT assays
Cell Lines PDAC cell lines
Concentrations 0.5-4.0 μM
Incubation Time 48 h
Results In BxPC-3, CFPAC-1, and HPAC cells, VS-5584 treatment decreased the percentage of cells in the S and G2/M cell cycle phases and increased the percentage of G0/G1 cells
Rating
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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: VS-5584 supplier, PI3K, inhibitors

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