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VRT752271

Cat. No. M5345

VRT752271 Structure

Synonym: BVD-523, Ulixertinib

Size Price Availability Quantity
5mg USD 100 In stock
10mg USD 150 In stock
50mg USD 420 In stock
100mg USD 660 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

In an A375 melanoma cell line containing a b-RAFV600E mutation, Ulixertinib reduces the levels of phosphorylated ERK2 (pERK) and of the phosphorylation of the downstream kinase RSK (pRSK) with IC50 of 4.1/0.14 μM, respectively. Ulixertinib also inhibits A375 cell proliferation with IC50 of 180 nM.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 433.33
Formula C21H22Cl2N4O2
CAS Number 869886-67-9
Purity >99%
Solubility 86 mg/mL in DMSO
Storage at -20°C
References

Determination of ulixertinib in mice plasma by LC-MS/MS and its application to a pharmacokinetic study in mice.
Kumar R, et al. J Pharm Biomed Anal. 2016 Jun 5;125:140-4. PMID: 27017572.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: VRT752271, BVD-523, Ulixertinib supplier, ERK, inhibitors

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