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VPC-80051

Cat. No. M10456
VPC-80051 Structure
Size Price Availability Quantity
10mg USD 576  USD640 In stock
25mg USD 864  USD960 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

VPC-80051 is a novel inhibitor of hnRNP A1 that targets the hnRNP A1 RBD. VPC-80051 interacts directly with hnRNP A1 RBD and reduces AR-V7 messenger levels in 22Rv1 CRPC cell line.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 301.29
Formula C16H13F2N3O
CAS Number 877969-69-2 (Racemic)
Purity >98%
Solubility DMSO
Storage at -20°C
References

Computer-Aided Discovery of Small Molecules Targeting the RNA Splicing Activity of hnRNP A1 in Castration-Resistant Prostate Cancer
Lavinia A Carabet, et al. Molecules. 2019 Feb 20;24(4):763. PMID: 30791548.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: VPC-80051 supplier, inhibitors

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