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Vortioxetine

Cat. No. M6058
Vortioxetine Structure
Synonym:

Lu AA 21004

Size Price Availability Quantity
10mg USD 130 In stock
50mg USD 520 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Vortioxetine (Lu AA21004) is a multimodal serotonergic agent, inhibits 5-HT1A, 5-HT1B, 5-HT3A, 5-HT7 receptor and SERT with IC50 of 15 nM, 33 nM, 3.7 nM, 19 nM and 1.6 nM, respectively.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 298.45
Formula C18H22N2S
CAS Number 508233-74-7
Purity >98%
Solubility 10 mM in DMSO
Storage at -20°C
References

Vortioxetine, a novel antidepressant with multimodal activity: review of preclinical and clinical data.
Sanchez C, et al. Pharmacol Ther. 2015 Jan;145:43-57. PMID: 25016186.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Vortioxetine, Lu AA 21004 supplier, 5-HT Receptor, inhibitors

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