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Vitexin-4-O-glucoside

Cat. No. M10613
Vitexin-4-O-glucoside Structure
Size Price Availability Quantity
5mg USD 135  USD135 In stock
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Quality Control & Documentation
Biological Activity

Vitexin-4''-O-glucoside is a flavonoid derived from the leaves of Crataegus pinnatifida.

Chemical Information
Molecular Weight 594.52
Formula C27H30O15
CAS Number 178468-00-3
Form Solid
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Kexin Hou, et al. J Chromatogr A. Ionic liquids-lithium salts pretreatment followed by ultrasound-assisted extraction of vitexin-4″-O-glucoside, vitexin-2″-O-rhamnoside and vitexin from Phyllostachys edulis leaves

[2] Hongjuan Li, et al. J Chromatogr B Analyt Technol Biomed Life Sci. Separation of vitexin-4″-O-glucoside and vitexin-2″-O-rhamnoside from hawthorn leaves extracts using macroporous resins

[3] Yinghui Chen, et al. J Pharm Pharmacol. Hepatic and gastrointestinal first-pass effects of vitexin-4″-O-glucoside in rats

[4] Xi Xiang Ying, et al. Eur J Drug Metab Pharmacokinet. Pharmacokinetics of vitexin-4″-O-glucoside in rats after intravenous application

[5] Wenjun Zhang, et al. J Chromatogr B Analyt Technol Biomed Life Sci. Simultaneous determination of vitexin-4''-O-glucoside, vitexin-2''-O-rhamnoside, rutin and vitexin from hawthorn leaves flavonoids in rat plasma by UPLC-ESI-MS/MS

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