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Vitamin K1

Cat. No. M14420
Vitamin K1 Structure
Synonym:

Phylloquinone; Phytomenadione

Size Price Availability Quantity
500mg USD 30  USD30 In stock
1g USD 45  USD45 In stock
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Biological Activity

Vitamin K1 a naturally occurring vitamin required for blood coagulation and bone and vascular metabolism.

Chemical Information
Molecular Weight 450.7
CAS Number 84-80-0
Solubility (25°C) Ethanol ≥ 50 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Asim Cengiz Akbulut, et al. Vitamin K2 Needs an RDI Separate from Vitamin K1

[2] Maurice Halder, et al. Vitamin K: Double Bonds beyond Coagulation Insights into Differences between Vitamin K1 and K2 in Health and Disease

[3] Rachel B Britt, et al. Characterizing the Severe Reactions of Parenteral Vitamin K1

[4] Gilles J Basset, et al. Phylloquinone (Vitamin K1): Occurrence, Biosynthesis and Functions

[5] Joline W J Beulens, et al. The role of menaquinones (vitamin K₂) in human health

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Keywords: Vitamin K1, Phylloquinone; Phytomenadione supplier, Metabolite/Endogenous Metabolite, inhibitors, activators


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