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Vitamin A

Cat. No. M19285
Vitamin A Structure
Size Price Availability Quantity
10mg USD 68  USD68 In stock
25mg USD 120  USD120 In stock
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Quality Control & Documentation
Biological Activity

Vitamin A (Retinol) is a naturally occuring fat-soluble vitamin that is important for normal vision, the immune system, and reproduction. It also plays roles in normal functioning of heart, lungs, kidneys, and other organs.

Product Citations
Chemical Information
Molecular Weight 286.45
Formula C15H22O3
CAS Number 68-26-8
Solubility (25°C) DMSO ≥ 40 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Akimori Wada. Yakugaku Zasshi. [Chemical Biology Studies Using Vitamin A Analogs]

[2] Shimrit Bar-El Dadon, et al. Crit Rev Food Sci Nutr. Vitamin A and the epigenome

[3] H Herschel Conaway, et al. Endocr Rev. Vitamin a metabolism, action, and role in skeletal homeostasis

[4] M I Dawson. Curr Pharm Des. The importance of vitamin A in nutrition

[5] C J Bates. Lancet. Vitamin A

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