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Vinorelbine Tartrate

Cat. No. M3120
Vinorelbine Tartrate Structure
Synonym:

KW-2307; Nor-5'-anhydrovinblastine ditartrate

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
5mg USD 42  USD42 In stock
10mg USD 68  USD68 In stock
50mg USD 215  USD215 In stock
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Quality Control & Documentation
Biological Activity

Vinorelbine Tartrate is a semi-synthetic vinca alkaloid, and inhibits mitosis through interaction with tubulin. Vinorelbine ditartrate inhibits the proliferation of Hela cells with IC50 of 1.25 nM.

Protocol (for reference only)
Cell Experiment
Cell lines
Preparation method
Concentrations
Incubation time
Animal Experiment
Animal models Bladder (BXF1299), pancreas (PAXF546), kidney (RXF944LX), colon (DLD-1, HT-29, TC37), central nervous system (SF-295), small cell lung (NCI-H69) and prostate (PC-3) xenografts
Formulation Sterile 0.9% sodium chloride solution
Dosages ~10 mg/kg
Administration i.p.
Chemical Information
Molecular Weight 1079.11
Formula C45H54N4O8.2C4H6O6
CAS Number 125317-39-7
Solubility (25°C) DMSO ≥ 60 mg/mL
Water ≥ 60 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Peng Yuan, et al. Eribulin mesilate versus vinorelbine in women with locally recurrent or metastatic breast cancer: A randomised clinical trial

[2] Dongsheng Yue, et al. Erlotinib versus vinorelbine plus cisplatin as adjuvant therapy in Chinese patients with stage IIIA EGFR mutation-positive non-small-cell lung cancer (EVAN): a randomised, open-label, phase 2 trial

[3] Gianni Bisogno, et al. Vinorelbine and continuous low-dose cyclophosphamide as maintenance chemotherapy in patients with high-risk rhabdomyosarcoma (RMS 2005): a multicentre, open-label, randomised, phase 3 trial

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Keywords: Vinorelbine Tartrate, KW-2307; Nor-5'-anhydrovinblastine ditartrate supplier, Microtubule, inhibitors, activators

 
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