The behavior of vinflunine in routine clinical practice resembles that of the pivotal phase III randomized study. Vinflunine（VFL）-EPR combination is feasible with manageable toxicity. The antitumour activity was promising and supports further evaluation. It underscores a critical function for VFL in cell-cell adhesions of epithelial bladder tumour cells, suggesting a novel molecular mechanism by which VFL may impact upon EMT and metastasis.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
Safety and effectiveness of vinflunine in patients with metastatic transitional cell carcinoma of the urothelial tract after failure of one platinum-based systemic therapy in clinical practice.
Castellano D, et al. BMC Cancer. 2014 Oct 24;14:779. PMID: 25342282.
Role of the microtubule-targeting drug vinflunine on cell-cell adhesions in bladder epithelial tumour cells.
Aparicio LA, et al. BMC Cancer. 2014 Jul 10;14:507. PMID: 25012153.
A phase I clinical and pharmacokinetic study evaluating vinflunine in combination with epirubicin as first-line treatment in metastatic breast cancer.
Chan S, et al. Cancer Chemother Pharmacol. 2014 May;73(5):903-10. PMID: 24627219.
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