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Vinflunine

Cat. No. M3723
Vinflunine Structure
Size Price Availability Quantity
5mg USD 140 In stock
10mg USD 260 In stock
50mg USD 795 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

The behavior of vinflunine in routine clinical practice resembles that of the pivotal phase III randomized study. Vinflunine(VFL)-EPR combination is feasible with manageable toxicity. The antitumour activity was promising and supports further evaluation. It underscores a critical function for VFL in cell-cell adhesions of epithelial bladder tumour cells, suggesting a novel molecular mechanism by which VFL may impact upon EMT and metastasis.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 816.93
Formula C45H54F2N4O8
CAS Number 162652-95-1
Purity >99%
Solubility DMSO
Storage at -20°C
References

Safety and effectiveness of vinflunine in patients with metastatic transitional cell carcinoma of the urothelial tract after failure of one platinum-based systemic therapy in clinical practice.
Castellano D, et al. BMC Cancer. 2014 Oct 24;14:779. PMID: 25342282.

Role of the microtubule-targeting drug vinflunine on cell-cell adhesions in bladder epithelial tumour cells.
Aparicio LA, et al. BMC Cancer. 2014 Jul 10;14:507. PMID: 25012153.

A phase I clinical and pharmacokinetic study evaluating vinflunine in combination with epirubicin as first-line treatment in metastatic breast cancer.
Chan S, et al. Cancer Chemother Pharmacol. 2014 May;73(5):903-10. PMID: 24627219.

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  Catalog
Abmole Inhibitor Catalog 2017




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