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Vilanterol

Cat. No. M4820
Vilanterol Structure
Synonym:

GW642444, VI

Size Price Availability Quantity
10mM*1mL in DMSO USD 118  USD118 In stock
5mg USD 110  USD110 In stock
10mg USD 165  USD165 In stock
50mg USD 490  USD490 In stock
100mg USD 710  USD710 In stock
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Quality Control & Documentation
Biological Activity

Vilanterol(GW642444, Veranterol) is a long-acting β2-AR agonist. PEC50 of β2-AR, β1-AR and β3-AR were 10.37, 6.98, 7.36, respectively.

Chemical Information
Molecular Weight 486.43
Formula C24H33Cl2NO5
CAS Number 503068-34-6
Solubility (25°C) DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Slack RJ, et al. J Pharmacol Exp Ther. In vitro pharmacological characterization of vilanterol, a novel long-acting β2-adrenoceptor agonist with 24-hour duration of action.

[2] Hanania NA, et al. Chest. The efficacy and safety of the novel long-acting β2 agonist vilanterol in patients with COPD: a randomized placebo-controlled trial.

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Keywords: Vilanterol, GW642444, VI supplier, Adrenergic Receptor, inhibitors, activators


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