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Vidofludimus

Cat. No. M4876

Vidofludimus Structure

Synonym: SC12267, 4SC-101

Size Price Availability Quantity
5mg USD 150 In stock
10mg USD 250 In stock
50mg USD 1000 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Vidofludimus attenuates IL-17 secretion from colonic strips by inhibition of STAT3 and NF-κB activation.In MRLlpr/lpr mice, Vidofludimus (300 mg/kg, p.o.) reduces systemic autoimmunity and improves Lupus Nephritis.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 355.36
Formula C20H18FNO4
CAS Number 717824-30-1
Purity >99%
Solubility DMSO 100 mg/mL
Water <1 mg/mL
Storage at -20°C
References

4SC-101, a novel small molecule dihydroorotate dehydrogenase inhibitor, suppresses systemic lupus erythematosus in MRL-(Fas)lpr mice.
Kulkarni OP, et.al. Am J Pathol. 2010 Jun;176(6). PMID: 20413687.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Vidofludimus, SC12267, 4SC-101 supplier, Dehydrogenase, inhibitors

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