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Vidofludimus

Cat. No. M4876
Vidofludimus Structure
Synonym:

SC12267, 4SC-101

Size Price Availability Quantity
10mM*1mL in DMSO USD 60  USD60 In stock
5mg USD 77  USD77 In stock
10mg USD 126  USD126 In stock
50mg USD 363  USD363 In stock
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Quality Control & Documentation
Biological Activity

Vidofludimus(4SC-101; SC12267) is an immunosuppressant that inhibits DHODH and inhibits il-17 secretion without affecting lymphocyte proliferation.

Chemical Information
Molecular Weight 355.36
Formula C20H18FNO4
CAS Number 717824-30-1
Solubility (25°C) DMSO 100 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Kulkarni OP, et.al. Am J Pathol. 4SC-101, a novel small molecule dihydroorotate dehydrogenase inhibitor, suppresses systemic lupus erythematosus in MRL-(Fas)lpr mice.

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Keywords: Vidofludimus, SC12267, 4SC-101 supplier, DHODH, inhibitors, activators


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