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Vibegron

Cat. No. M9201
Vibegron Structure
Synonym:

MK-4618

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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Vibegron is a potent and selective beta 3 adrenergic receptor agonist. Vibegron induced lipolysis, thermogenesis, and antihyperglycemic activity in preclinical species.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 444.52
Formula C26H28N4O3
CAS Number 1190389-15-1
Purity >98%
Solubility DMSO
Storage at -20°C
References

Discovery of Vibegron: A Potent and Selective β3 Adrenergic Receptor Agonist for the Treatment of Overactive Bladder.
Edmondson SD, et al. J Med Chem. 2016 Jan 28;59(2):609-23. PMID: 26709102.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Vibegron, MK-4618 supplier, Adrenergic Receptor, inhibitors

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