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Verinurad

Cat. No. M9351
Verinurad Structure
Synonym:

RDEA3170

Size Price Availability Quantity
10mM*1mL in DMSO USD 88  USD88 In stock
5mg USD 80  USD80 In stock
10mg USD 110  USD110 In stock
25mg USD 200  USD200 In stock
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Quality Control & Documentation
Biological Activity

Verinurad, also known as RDEA3170, is an organic anion transporter URAT1 inhibitor with an IC50 of 25 nM.

Chemical Information
Molecular Weight 348.42
Formula C20H16N2O2S
CAS Number 1352792-74-5
Solubility (25°C) DMSO ≥ 50 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Tan PK, et al. Sci Rep. Discovery and characterization of verinurad, a potent and specific inhibitor of URAT1 for the treatment of hyperuricemia and gout.

[2] Diaz-Torne C, et al. Curr Opin Rheumatol. New medications in development for the treatment of hyperuricemia of gout.

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Keywords: Verinurad, RDEA3170 supplier, URAT1, inhibitors, activators


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