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Venlafaxine

Cat. No. M6051
Venlafaxine Structure
Synonym:

Wy 45030

Size Price Availability
10mg USD 60  USD60 4-7 Days
50mg USD 180  USD180 4-7 Days
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Quality Control & Documentation
Biological Activity

Venlafaxine is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI) class.

Chemical Information
Molecular Weight 277.4
Formula C17H27NO2
CAS Number 93413-69-5
Solubility (25°C) 10 mM in DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Jiang F, et al. Psychopharmacology (Berl). The influences of CYP2D6 genotypes and drug interactions on the pharmacokinetics of venlafaxine: exploring predictive biomarkers for treatment outcomes.

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