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VAS2870

Cat. No. M8274
VAS2870 Structure
Size Price Availability Quantity
5mg USD 60  USD60 In stock
10mg USD 110  USD110 In stock
25mg USD 210  USD210 In stock
50mg USD 380  USD380 In stock
100mg USD 680  USD680 In stock
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Quality Control & Documentation
Biological Activity

VAS2870 is a cell-permeable and specific NADPH oxidase (NOX) inhibitor that effectively suppresses growth factor-mediated ROS liberation in VSMC.

Chemical Information
Molecular Weight 360.39
Formula C18H12N6OS
CAS Number 722456-31-7
Solubility (25°C) DMSO: ≥5 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Wan Jung Lu, et al. VAS2870 and VAS3947 attenuate platelet activation and thrombus formation via a NOX-independent pathway downstream of PKC

[2] Pavel V Avdonin, et al. VAS2870 Inhibits Histamine-Induced Calcium Signaling and vWF Secretion in Human Umbilical Vein Endothelial Cells

[3] Janez Simenc, et al. NADPH oxidase inhibitor VAS2870 prevents staurosporine-induced cell death in rat astrocytes

[4] Kirstin Wingler, et al. VAS2870 is a pan-NADPH oxidase inhibitor

[5] Qi-An Sun, et al. Off-target thiol alkylation by the NADPH oxidase inhibitor 3-benzyl-7-(2-benzoxazolyl)thio-1,2,3-triazolo[4,5-d]pyrimidine (VAS2870)

Related NADPH Oxidase Products
Fluoflavine

Fluoflavine is a selective NOX1 inhibitor with an IC50 value of 90 nM.Fluoflavine is >100 times more selective for NOX1 than NOX2, NOX3, NOX4, and has an IC50 >10 μM for all of them.Fluoflavine was shown to be a selective inhibitor of NOX1 with an IC50 of 360 nM in HEK293 cells.

NoxA1ds

NoxA1ds is a highly efficacious and selective Nox1 (NADPH oxidase isoform 1) inhibitor.

GLX481369

GLX481369 is a redox active substance.

Noxa B BH3

Noxa B BH3 is a biological active peptide.

Noxa A BH3

Noxa A BH3 is a biological active peptide.

  Catalog
Abmole Inhibitor Catalog




Keywords: VAS2870 supplier, NADPH Oxidase, inhibitors, activators


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