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Varlilumab

Cat. No. M21480
Varlilumab Structure
Synonym:

CDX-1127

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Biological Activity

Varlilumab (CDX-1127) is a first-in-class monoclonal antibody to human IgG1 against CD27. Varlilumab has antitumor activity.

Chemical Information
CAS Number 1393344-72-3
Solubility (25°C) N/A
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Rachel E Sanborn, et al. J Immunother Cancer. Safety, tolerability and efficacy of agonist anti-CD27 antibody (varlilumab) administered in combination with anti-PD-1 (nivolumab) in advanced solid tumors

[2] Stephen M Ansell, et al. Blood Adv. Safety and activity of varlilumab, a novel and first-in-class agonist anti-CD27 antibody, for hematologic malignancies

[3] Angelika M Starzer, et al. ESMO Open. New emerging targets in cancer immunotherapy: CD27 (TNFRSF7)

[4] Capucine Baldini, et al. Bull Cancer. Immunothérapie des glioblastomes

[5] Howard A Burris, et al. J Clin Oncol. Safety and Activity of Varlilumab, a Novel and First-in-Class Agonist Anti-CD27 Antibody, in Patients With Advanced Solid Tumors

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Keywords: Varlilumab, CDX-1127 supplier, inhibitors, activators


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