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Valsartan

Cat. No. M3507
Valsartan Structure
Synonym:

CGP 48933

Size Price Availability Quantity
10mg USD 35  USD35 In stock
50mg USD 100  USD100 In stock
100mg USD 140  USD140 In stock
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Quality Control
Biological Activity

Valsartan (Diovan) is an angiotensin II receptor antagonist with IC50 of ranging from 39.5 to116 uM. By blocking the action of angiotensin, valsartan dilates blood vessels and reduces blood pressure. In the Value trial, the angiotensin II receptor blocker valsartan produced a statistically significant 19% (p=0.02) relative increase in the prespecified secondary end point of myocardial infarction (fatal and non-fatal) compared with amlodipine. The CHARM-alternative trial showed a significant +52% (p=0.025) increase in myocardial infarction with candesartan (versus placebo) despite a reduction in blood pressure.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 435.52
Formula C24H29N5O3
CAS Number 137862-53-4
Purity 98.68%
Solubility DMSO 77 mg/mL
Storage at -20°C
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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Valsartan, CGP 48933 supplier, Angiotensin Receptor, inhibitors

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