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Valproic acid sodium salt

Cat. No. M1876
Valproic acid sodium salt Structure

Sodium valproate

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Free Sample (0.5-1 mg)  USD 0 In stock
500mg USD 50 In stock
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Biological Activity

Valproic acid sodium salt (Sodium valproate) is a potent inhibitor of histone deacetylase (HDAC) in vitro (IC50 = 400 μM for HDAC1) which is reported to enhance central GABAergic neurotransmission and inhibit Na+ channels. Sodium valproate (VPA) can inhibit the proliferation of tumor cells by inducing G0/G1 phase arrest and cell apoptosis. Valproic Acid significantly lowers serum concentrations of olanzapine-an interaction effect comparable with smoking. Similarly, heat shock protein 70 (HSP70) levels were time-dependently up-regulated by Valproic acid in the cortex and striatum of both ipsilateral and contralateral sides of MCAO rats and in these brain areas of normal rats. Sodium valproate (VPA) is neuroprotective in the cerebral ischemia model and suggest that the protection mechanisms may involve HDAC inhibition and HSP induction.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 166.19
Formula C8H15NaO2
CAS Number 1069-66-5
Purity >99%
Solubility DMSO ≥30 mg/mL
Water ≥50 mg/mL
Storage at -20°C
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Keywords: Valproic acid sodium salt, Sodium valproate supplier, HDAC, inhibitors

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